The objective of this study was to determine the phenolic compounds and antioxidants activity in different ripening stages of papaya fruit. It is an herbaceous plant that grows in tropical and sub. This work describes biochemical constituents of leaves of carica papaya. Therefore, the present investigation has been carried out to find out the antioxidant activity of c. Invitro antioxidant capacity of pp was determined by ferric reducing antioxidant potential 31. The major free sugars identified were sucrose, glucose, and fructose. The present study was designed to explore the toxicological and antioxidant potential of dried c.
The hypoglycemic activities of carica papaya have been previously described for its fruit and leaves aruoma et al. Carica papaya is a tropical plant that is traditionally used. The objective of this study was to elucidate in detail the antioxidant capacity of c. Result of the antimicrobial activity of root extracts of carica papaya s. Fermented papaya preparation fpp is a product of yeast fermentation of carica papaya linn. Cytoprotective and dna protective activity of carica. Carica papaya is widely cultivated throughout the world and is used as a food and also as a traditional medicine, particularly as an antiseptic and contraceptive. Other compounds identified included two organic acids malic acid and citric acid and 20 amino acids. Diabetes the killer disease known worldwide has been implicated to generate oxidative stress and carica papaya has been suggested to manage this effect. Compositional difference in antioxidant and antibacterial activity of all parts of the carica papaya using different solvents. Chemical composition of various part of carica papaya plant are described table 5.
This study was conducted to establish polyphenols, flavonoids and antioxidant potential profile of extracts of all major parts of the c. Antioxidant properties of unripe carica papaya fruit. Carica papaya is widely used in folk medicine as herbal remedy to prevent, protect against, and cure several diseases. Patients were advised to eat papaya fruit frequently during dengue fever epidemic in pakistan by physicians. It has been documented in literature for its use by natives of various parts of world and also for its antiinflammatory. Oxidative damage caused by free radicals has major implications in many chronic diseases. Antioxidant activity of carica papaya seed extracts on. Antioxidant activity of papaya peel and developed chapathis. This study optimised conditions for the extraction of saponins from pl and assessed.
Pdf phytochemical and pharmacological investigation of. Antioxidant activity of fermented papaya preparation fpp in the absence and presence of saliva. Antibacterial activity of seed and leaf extract of carica papaya var. Models of acute gastric ulcer induction by ethanol and indomethacin and of chronic ulcer by acetic acid were used. In antimicrobial activity investigation, methanolic crude extract of. Pawpaw seeds from riped pawpaw carica papaya fruits was obtained from asmau farms, along gombi road, jimeta. The papaya carica papaya leaf pl contains high levels of saponins and polyphenolic compounds, and historically, it has been used as a folk medicine for numerous ailments, including cancer. Research article administration dependent antioxidant effect. Tpc was determined by folinciocalteu method, while antioxidant. Carica papaya holds significant antioxidant and free radical scavenging potential.
Many scientific works have been carried out to evaluate the benefit of different parts of papaya plant including fruits, seeds, leaves, rind, shoots, roots or latex 11. Pusa dwarf linn jyotsna kiran peter, yashab kumar, priyanka pandey and harison masih department of microbiology and fermentation technology, jsbb, shiats deemed to be university, naini, up, india 211008. Wattanapitayakul 1 departmentofpharmacology,facultyofmedicine,srinakharinwirotuniversity,ail and. It has been proven that high consumption of fruit and vegetable lowers the risks of cardiovascular and other oxidative stressrelated diseases. Administration dependent antioxidant effect of carica. The present study aimed to evaluate the antioxidative potential of selected carica papaya peel and seed by determining their total phenolic content tpc and antioxidant activities. Tp was determined by folinciocalteus method, while antioxidant activities were evaluated using dpph radical scavenging ability and ferric reducingantioxidant power frap assays. This study was conducted using only the methanolic extrarct. Phytochemical screening, antimicrobial and antioxidant. It has been documented in literature for its use by natives of various parts of world and also for its antiinflammatory, antitumour, antidiabetic effects and many others. The results of present study revealed that phenols, flavonoid and antioxidant activity of papaya peel paste and powder. The carica papaya extract cpe have hepatoprotective effect against carbon tetrachloride intoxicated rats and it may be mediating its protective effects either by decreasing the metabolic activation of carbon tetrachloride, or by acting as a chainbreaking antioxidant for scavenging free radicals or by a combination of these effects. Carica papaya, solo, solomix, antimicrobial, antioxidant 1. The extract was again found to possess significantly lower levels of activity relative to the commercial samples, with egcg proving to be the most potent antioxidant.
This study demonstrates the efficacy of ethanolic leaf extracts of c. This study aimed to determine the effect of extraction media, solventtowater ratio and extraction time on total phenolics tp and antioxidant activities of the peel and seed of carica papaya variety sekaki. The antioxidant activities of solo and solomix showed ic50 of 1. This study was conducted to compare the total antioxidant activity taa, total phenolic content tpc and total flavonoid content tfc from the different parts of papaya tree including their ripe and unripe fruit, seeds and the young leaves. The objective of this study was to determine the invitro antioxidant activity of papaya seeds and their effect on endogenous antioxidant enzymes in hepg2 cells. This study was conducted to compare the total antioxidant activity taa, total phenolic content tpc and total flavonoid content tfc from the different parts of papaya tree including their. Antibacterial activity of seed and leaf extract of carica. Papaya as an alternative antibiotic for the development of newer antibacterial agents. Papaya seeds were extracted in methanol and hexane.
Antioxidant potential of carica papaya peel and seed yee kwang ang1, winne cm sia2, hock eng khoo3, hip seng yim4 department of food. Papaya possess excellent medicinal properties for treatment of different ailments. Antioxidant potential of carica papaya peel and seed issuu. Antioxidant potentials of iranian carica papaya juice in.
The antioxidant properties of ucp were investigated using the assays of frap and orac and specific. The gastric juice and mucus parameters were evaluated using the pylorus ligation model, and the. An investigation of the antioxidant property of carica. Total antioxidant activity of papaya leaf extract was also assessed by comparison against the same set of compounds fig. Effect of drying methods on the phytochemicals composition. Different parts of the plant are employed in the treatment of different human and. Phytochemical screening and hypoglycemic activity of. Influence of ripening stages on antioxidant properties of. No toxic concentrations of vitamin c 50, 100, 150, 200, and 250. Antioxidant analysis of different parts of carica papaya. The by products of papaya is approximately 20 25% of fruit weight and it is a good source of minerals, fiber and phenolic compounds that have a wide range of pharmacological activities.
Effect of extraction conditions on total phenolic compounds. Papaya seeds exhibited invitro antioxidant activity. Leaves, fruit and seeds of the carica papaya are used as ethno medicine. This study was therefore aimed at evaluating the antioxidant activity of c. Carica papaya cp otherwise known as the papaya pear is found in most tropical and subtropical countries of the world. The purpose of the present study is to evaluate the antioxidant activity of the methanolic extract of the leaves of carica papaya using 1,1diphenyl2picrylhydrazine dpph. Antioxidant effect of aqueous carica papaya seeds extract. Papaya seeds may be as functional food ingredient in alleviate oxidative stress. Materials and methods food sampling convenience sampling method was used to obtain the samples. Antimicrobial activity of carica papaya, piper nigrum and. Antiulcerogenic activity of carica papaya seed in rats. Papaya carica papaya linn is commonly called as pawpaw and it belongs to the family caricaceae.
The objective of this current study was to evaluate the antioxidant properties of carica papaya extract in cadmium induced prefrontal cortex toxicity through a critical measurement of antioxidant enzymes activities in the brain tissue. Ethanolic and methanolic extracts of carica papaya the ethanol and methanol extracts of leaves of carica papaya showed profound activity against the gram positive organisms than gram negative organisms. Administration dependent antioxidant effect of carica papaya. Hongkong is an economically important fruit crop grown in malaysia. Antifertility activity the antifertility effects of carica papaya were investigated by feeding adult and. The fruits of papaya are much sought after by human as valuable foodstuff and have antihypertensive activity. Antioxidant activity of papaya seed extracts against h2o2. The properties of papaya fruit and other parts of the plant are also well known in traditional system of medicine.
Carica papaya cp, belongs to the plant family caricaceae, is an economically important fruit crop worldwide 10. Cytotoxicity of the carica papaya aerial parts extracts was carried out by using mtt colormetric methods. Due to which the research in molecular mechanisms of their anticancer properties is increasing rapidly. Compositional difference in antioxidant and antibacterial. In this work, supercritical fluid extraction sfe for the recovery of phenolic antioxidants from papaya agroindustrial waste seeds was explored, making use of neat supercritical co2 and co2 added with ethanol co2etoh. The antioxidant effect of fermented papaya preparation in. Activity of carica papaya leaves of extract to three test species. The results in table 2 and 3 showed that carica papaya extracts were minimal toxic and showed antihiv1 activity. Antioxidant and apoptotic activity of papaya peel extracts. It can be used for treatment of a numerous diseases like warts, corns, sinuses, eczema, cutaneous tubercles, glandular tumors, blood pressure, dyspepsia, constipation, amenorrhoea, general debility. Extraction techniques for bioactive compounds and antioxidant. The immunity activities of ps were evaluated using the carbon clearance test and serum hemolysin analysis in mice. These curative properties are based on the presence in different parts of the plant of phytochemical nutrients with antioxidant effect.
Papaya seed extracts induced endogenous antioxidant enzymes in hepg2 cells. Carica papaya belongs to the family caricaceae, which is a fast growing erect, usually unbranched tree or shrub 78m with copious latex, land trunk about 20cm in diameter. Carica papaya is a well known medicinal plant used in the west and asian countries to cope several diseases. In some parts of asia, the young leaves of the papaya are steamed and eaten like spinach. Nov 25, 2014 the purpose of the present study was to evaluate the gastroprotective and healing effects of the methanolic extract of the seed of the papaya carica papaya l. Uses, side effects, interactions, dosage, and warning. Pdf antioxidant activity of seed extracts of annona. Thus papaya seeds offered protection to cells from oxidative stress. Staphylococcus aureus, staphylococcus epidermidis were found to be inhibited maximum amongst the test cultures used. Papaya seeds are discarded after consuming the fruit, but they contain many bioactive compounds. Antioxidant and apoptotic activity of papaya peel extracts in. The antioxidant effect of fermented papaya preparation in the.
To examine the potential role of carica papaya as anticancer therapy, we analyzed in this report the antitumor activity of the aqueous extract of the leaves of carica papaya cp against various. Carica papaya and screening of their biological activities like, antimicrobial and free antioxidant activities. Introduction carica papaya linn belonging to family caricaceae is commonly known as papaya in english, papita in. Test microbes zone of inhibition due to carica papaya root extract 1mgml in mm benzene extract acetone extract aqueous extract 1. The present study evaluated the antioxidant and immunostimulant activities of carica papaya l aqueous extract against acrylamide toxicity. Papaya peels pp are discarded after consuming the fruit. Antioxidant analysis of different parts of carica papaya abstract this study was conducted to compare the total antioxidant activity taa, total phenolic content tpc and total flavonoid content tfc from the different parts of papaya tree including their ripe and unripe fruit, seeds and the young leaves. Antiinflammatory and immunomodulatory properties of carica papaya saurabh pandey, peter j. The free radical scavenging capacity by dpph assays of chilean papaya, based on their trolox equivalent values in free fraction, did not differ widely and ranged from 15. The antioxidant activities of the ethanol, petroleum ether, ethyl acetate, nbutanol and water extract fractions from the seeds of papaya were evaluated in this study. Seed the poor countries in tropical region, papaya peel is i nt roduc t ion used for cooking as one of the dishes. May 23, 2009 the antioxidative activities of water extract we and crude hotwater soluble polysaccharide ps from ficus carica l.
Modulation of endogenous glutathione gsh, superoxide dismutase sod, catalase cat, glutathione. Introduction cancer is a leading cause of death worldwide, it is a dreadful disease, and combating this disease is of great importance to public health. Pharmacological investigation of leaves of carica papaya. They may possess antioxidant 17, anticancer 18 and antiinflam matory 19 properties. Influence of different extraction parameters on antioxidant. The present study was designed to perform phytochemical and physicochemical analyses of carica papaya leaves, and to. Carica papaya, aerial parts, anticancer activity, phytoconstituents. Different parts of this plant which include the leaves, fruit. Cells posses a variety of primary and secondary defenses against lipid peroxidation and other deleterious effect of oxidative damage. Materials and methods sample collection and preparation fresh c. Graphical representation of antimicrobial activity of carica papaya leaves of.
Antioxidant and immunity activity of water extract and crude. Antioxidant capacity measured in methanol extracts by using dpph, frap, and swv assays are shown in table 2. It is native to the tropics of the americas but now is widely cultivated in other tropical regions of the world for its edible melonlike fruit, which is available throughout the year 125. For papaya seed, the deionised water extract had the highest tp and antioxidant activity at all extract concentrations, except for scavenging activity at extract concentration of 50. Antioxidant capacity of juice from diff erent papaya carica. One such botanical source that has been reported to possess therapeutic effects is the papaya fruit webman et al. Pl is traditionally prepared by hot water extraction. The ethyl acetate fraction showed the strongest dpph and hydroxyl free radicalscavenging activities, and its activities were stronger than those of ascorbic acid and sodium benzoate, respectively. Whole fruit extract contains ferulic, pcoumaric, and ca eic acid, carotenoids, and vitamin c that.
Antioxidant activity and physicochemical properties. An investigation of the antioxidant property of carica papaya. M were added to the culture medium simultaneously with h 2 o 2 or during recovery. Antifertility activity the antifertility effects of carica papaya. Here we evaluated the effects of a tropical fruit, unripe carica papaya ucp, on endothelial protection against oxidative damage induced by h 2 o 2. Since protooncogene bcl2 and stress protective genes i.
Cytoprotective and dna protective activity of carica papaya. Two methods namely dpph radical scavenging activity and. Pdf an investigation of the antioxidant property of. The study revealed that the investigated alphatocopherol and the carica papaya juice gave the same effect of the antioxidative stress potential. Phytochemical screening of the polar extracts of carica. Antimicrobial activity and phytochemical analysis of.
Pharmacological activity of each division of carica papaya whole carica papaya has a unique pharmacological uses 4. Antioxidant vitamin c effect was differently exerted than extract. Antioxidant properties of carica papaya on cadmium. Original article clinical use of carica papaya leaf. One kilogram of fresh papaya carica papaya was purchased from pasar tani masjid jamek, serdang while five hundred grams of pickled. Solvent extracts of papaya carica papaya were investigated for the sugars, organic acids, amino acids, and antioxidant activities. Effect of carica papaya leaf extract capsule on platelet. Antiinflammatory and immunomodulatory properties of. G and research department of microbiology, marudupandiyar college, vallam, thanjavur district, tamil nadu, india.
Evaluation of antioxidant properties in fresh and pickled papaya. Pdf antioxidant potential of carica papaya peel and seed. Carica papaya belonging to the caricaceae family is an effective medicinal herb that is used as a folk medicine for the treatment of various diseases throughout the world including bangladesh. The objective of this study was to determine invitro antioxidant and apoptotic activity of pp extracts. Aqueous extract of carica papaya leaves exhibits antitumor. Antimicrobial activity and phytochemical analysis of carica. Jun 05, 2012 the carica papaya extract cpe have hepatoprotective effect against carbon tetrachloride intoxicated rats and it may be mediating its protective effects either by decreasing the metabolic activation of carbon tetrachloride, or by acting as a chainbreaking antioxidant for scavenging free radicals or by a combination of these effects. Carica papaya leaf extracts have also been used for a long time as an aboriginal remedy for various disorders, including cancer and infectious diseases. Phytochemical screening and hypoglycemic activity of carica. Hence, this study was designed to assess the effect of four drying methods, namely, airdrying, freezedrying, ovendrying and sundrying on the phytochemicals composition and antioxidant activities c. Researcharticle antioxidant properties of unripe carica papaya fruit extract and its protective effects against endothelial oxidative stress wattanasedjarisarapurin,1 wariyasanrattana,2,3 lindachularojmontri,4 khwandowkunchana,1 andsuvarak. Papaya seeds were known to give several health benefits 5, 6. Antioxidant capacity of juice from diff erent papaya carica papaya l. The powdered leaves of carica papaya was extracted with methanol.
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